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dc.contributor.authorDing, Qianwen
dc.contributor.authorZhang, Zhen
dc.contributor.authorLi, Yu
dc.contributor.authorLiu, Hongliang
dc.contributor.authorHao, Qiang
dc.contributor.authorYang, Yalin
dc.contributor.authorRingø, Einar
dc.contributor.authorOlsen, Rolf Erik
dc.contributor.authorClarke, Jihong Liu
dc.contributor.authorRan, Chao
dc.contributor.authorZhou, Zhigang
dc.date.accessioned2021-10-14T12:57:53Z
dc.date.available2021-10-14T12:57:53Z
dc.date.created2021-08-10T16:21:59Z
dc.date.issued2021-06-25
dc.identifier.citationiScience. 2021, 24 (6), .en_US
dc.identifier.issn2589-0042
dc.identifier.urihttps://hdl.handle.net/11250/2823084
dc.description.abstractPropionate and propionyl-CoA accumulation have been associated with the development of mitochondrial dysfunction. In this study, we show that propionate induces intestinal damage in zebrafish when fed a high-fat diet (HFD). The intestinal damage was associated with oxidative stress owing to compromised superoxide dismutase 2 (Sod2) activity. Global lysine propionylation analysis of the intestinal samples showed that Sod2 was propionylated at lysine 132 (K132), and further biochemical assays demonstrated that K132 propionylation suppressed Sod2 activity. In addition, sirtuin 3 (Sirt3) played an important role in regulating Sod2 activity via modulating de-propionylation. Finally, we revealed that intestinal oxidative stress resulting from Sod2 propionylation contributed to compositional change of gut microbiota. Collectively, our results in this study show that there is a link between Sod2 propionylation and oxidative stress in zebrafish intestines and highlight the potential mechanism of intestinal problems associated with high propionate levels.en_US
dc.language.isoengen_US
dc.publisherElsevier B.V.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titlePropionate induces intestinal oxidative stress via Sod2 propionylation in zebrafishen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 The Authorsen_US
dc.source.pagenumber24en_US
dc.source.volume24en_US
dc.source.journaliScienceen_US
dc.source.issue6en_US
dc.identifier.doi10.1016/j.isci.2021.102515
dc.identifier.cristin1925177
dc.source.articlenumber102515en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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