Blar i NIBIO Brage på forfatter "Branza-Nichita, Norica"
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Challenges and prospects of plant-derived oral vaccines against hepatitis b and c viruses
Pantazica, Ana-Maria Madalina; Cucos, Lia-Maria; Stavaru, Crina; Clarke, Jihong Liu; Branza-Nichita, Norica (Peer reviewed; Journal article, 2021-09-28)Hepatitis B and C viruses chronically affect approximately 3.5% of the global population, causing more than 800,000 deaths yearly due to severe liver pathogenesis. Current HBV vaccines have significantly contributed to the ... -
Efficient cellular and humoral immune response and production of virus-neutralizing antibodies by the Hepatitis B Virus S/preS1 16-42 antigen
Pantazica, Ana-Maria; Dobrica, Mihaela-Olivia; Lazar, Catalin; Scurtu, Cristina; Tucureanu, Catalin; Caras, Iuliana; Ionescu, Irina; Costache, Adriana; Onu, Adrian; Clarke, Jihong Liu; Stavaru, Crina; Branza-Nichita, Norica (Peer reviewed; Journal article, 2022-07-22)Despite the availability of improved antiviral therapies, infection with Hepatitis B virus (HBV) remains a3 significant health issue, as a curable treatment is yet to be discovered. Current HBV vaccines relaying on the ... -
Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus-neutralizing activity in vaccinated mice
Dobrica, Mihaela-Olivia; van Eerde, André; Tucureanu, Catalin; Onu, Adrian; Paruch, Lisa; Caras, Iuliana; Vlase, Ene; Steen, Hege; Haugslien, Sissel; Alonzi, Dominic; Zitzmann, Nicole; Bock, Ralph; Dubuisson, Jean; Popescu, Costin-Ioan; Stavaru, Crina; Clarke, Jihong Liu; Branza-Nichita, Norica (Peer reviewed; Journal article, 2021-05-18)Chronic infection with hepatitis C virus (HCV) remains a leading cause of liver-related pathologies and a global health problem, currently affecting more than 71 million people worldwide. The development of a prophylactic ... -
Lettuce-produced hepatitis C virus E1E2 heterodimer triggers immune responses in mice and antibody production after oral vaccination
Clarke, Jihong; Paruch, Lisa; Dobrica, Mihaela-Olivia; Caras, Iuliana; Tucureanu, Catalin; Onu, Adrian; Ciulean, Sonya; Stavaru, Crina; van Eerde, André; Wang, Yanliang; Steen, Hege; Haugslien, Sissel; Petrareanu, Catalina; Lazar, Catalin; Popescu, Costin-loan; Bock, Ralph; Dubuisson, Jean; Branza-Nichita, Norica (Journal article; Peer reviewed, 2017)The hepatitis C virus (HCV) is a major etiologic agent for severe liver diseases ( e.g . cirrhosis, fibrosis and hepatocellular carcinoma). Approximately 140 million people have chronic HCV infections and about 500 000 die ... -
Plant-made vaccines against viral diseases in humans and farm animals
Su, Hang; van Erde, André; Rimstad, Espen; Bock, Ralph; Branza-Nichita, Norica; Yakovlev, Igor; Liu Clarke, Jihong (Peer reviewed; Journal article, 2023-03-28)Plants provide not only food and feed, but also herbal medicines and various raw materials for industry. Moreover, plants can be green factories producing high value bioproducts such as biopharmaceuticals and vaccines. ...