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dc.contributor.authorKorsnes, Monica Suarez
dc.contributor.authorKolstad, Hilde Raanaas
dc.contributor.authorKleiveland, Charlotte Ramstad
dc.contributor.authorKorsnes, Reinert
dc.contributor.authorØrmen, Elin
dc.date.accessioned2016-02-19T13:45:45Z
dc.date.accessioned2017-08-25T07:55:44Z
dc.date.available2016-02-19T13:45:45Z
dc.date.available2017-08-25T07:55:44Z
dc.date.issued2016
dc.identifier.citationKorsnes, M. S., Kolstad, H., Kleiveland, C. R., Korsnes, R., & Ørmen, E. (2016). Autophagic activity in BC3H1 cells exposed to yessotoxin. Toxicology in Vitro, 32, 166-180.nb_NO
dc.identifier.issn0887-2333
dc.identifier.urihttp://hdl.handle.net/11250/2451818
dc.description.abstractThe marine toxin yessotoxin (YTX) can induce programmed cell death through both caspase-dependent and-independent pathways in various cellular systems. It appears to stimulate different forms of cellular stress causing instability among cell death mechanisms and making them overlap and cross-talk. Autophagy is one of the key pathways that can be stimulated by multiple forms of cellular stress which may determine cell survival or death. The present work evaluates a plausible link between ribotoxic stress and autophagic activity in BC3H1 cells treated with YTX. Such treatment produces massive cytoplasmic compartments as well as doublemembrane vesicles termed autophagosomes which are typically observed in cells undergoing autophagy. The observed autophagosomes contain a large amount of ribosomes associated with the endoplasmic reticulum (ER). Western blotting analysis of Atg proteins and detection of the autophagic markers LC3-II and SQSTM1/p62 by flow cytometry and immunofluorescence verified autophagic activity during YTX-treatment. The present work supports the idea that autophagic activity upon YTX exposure may represent a response to ribotoxic stress.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAutophagic activity in BC3H1 cells exposed to yessotoxinnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.date.updated2016-02-19T13:45:45Z
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).nb_NO
dc.source.pagenumber166-180nb_NO
dc.source.volume32nb_NO
dc.source.journalToxicology in Vitronb_NO
dc.identifier.doidoi:10.1016/j.tiv.2015.12.010
dc.identifier.cristin1313642


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