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dc.contributor.authorStuen, Snorre
dc.contributor.authorGrøva, Lise
dc.contributor.authorGranquist, Erik Georg
dc.contributor.authorSandstedt, Karin
dc.contributor.authorOlesen, Ingrid
dc.contributor.authorSteinshamn, Håvard
dc.identifier.citationActa Veterinaria Scandinavica. 2011, 53 .nb_NO
dc.description.abstractBackground It has been questioned if the old native Norwegian sheep breed, Old Norse Sheep (also called Norwegian Feral Sheep), normally distributed on coastal areas where ticks are abundant, is more protected against tick-borne infections than other Norwegian breeds due to a continuously high selection pressure on pasture. The aim of the present study was to test this hypothesis in an experimental infection study. Methods Five-months-old lambs of two Norwegian sheep breeds, Norwegian White (NW) sheep and Old Norse (ON) sheep, were experimentally infected with a 16S rRNA genetic variant of Anaplasma phagocytophilum (similar to GenBank accession number M73220). The experiment was repeated for two subsequent years, 2008 and 2009, with the use of 16 lambs of each breed annually. Ten lambs of each breed were inoculated intravenously each year with 0.4 ml A. phagocytophilum-infected blood containing approximately 0.5 × 106 infected neutrophils/ml. Six lambs of each breed were used as uninfected controls. Half of the primary inoculated lambs in each breed were re-challenged with the same infectious dose at nine (2008) and twelve (2009) weeks after the first challenge. The clinical, haematological and serological responses to A. phagocytophilum infection were compared in the two sheep breeds. Results The present study indicates a difference in fever response and infection rate between breeds of Norwegian sheep after experimental infection with A. phagocytophilum. Conclusion Although clinical response seems to be less in ON-lambs compared to NW-lambs, further studies including more animals are needed to evaluate if the ON-breed is more protected against tick-borne infections than other Norwegian breeds.nb_NO
dc.publisherBiomed Centralnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectSheep Breednb_NO
dc.subjectSerological Responsenb_NO
dc.subjectDaily Weight Gainnb_NO
dc.subjectClinical Reactionnb_NO
dc.subjectSheep Flocknb_NO
dc.titleA comparative study of clinical manifestations, haematological and serological responses after experimental infection with Anaplasma phagocytophilum in two Norwegian sheep breedsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holder© Stuen et al; licensee BioMed Central Ltd. 2011nb_NO
dc.source.journalActa Veterinaria Scandinavicanb_NO
dc.relation.projectNorges forskningsråd: 173174nb_NO

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