dc.contributor.author | Feng, Panpan | |
dc.contributor.author | Chen, Dawei | |
dc.contributor.author | Wang, Xia | |
dc.contributor.author | Li, Yanxia | |
dc.contributor.author | Li, Zhenyu | |
dc.contributor.author | Li, Boya | |
dc.contributor.author | Zhang, Yupeng | |
dc.contributor.author | Li, Wei | |
dc.contributor.author | Zhang, Jingru | |
dc.contributor.author | Ye, Jingjing | |
dc.contributor.author | Zhao, Baobing | |
dc.contributor.author | Li, Jingxin | |
dc.contributor.author | Ji, Chunyan | |
dc.date.accessioned | 2022-11-04T18:56:00Z | |
dc.date.available | 2022-11-04T18:56:00Z | |
dc.date.created | 2022-09-30T09:56:01Z | |
dc.date.issued | 2022-08-01 | |
dc.identifier.citation | Leukemia. 2022, 36 2180-2188. | en_US |
dc.identifier.issn | 0887-6924 | |
dc.identifier.uri | https://hdl.handle.net/11250/3030262 | |
dc.description.abstract | T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant leukemia with extremely limited treatment for relapsed patients. N6‐methyladenosine (m6A) reader insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) participates in the initiation and growth of cancers by communicating with various targets. Here, we found IGF2BP2 was highly expressed in T-ALL. Gain and loss of IGF2BP2 demonstrated IGF2BP2 was essential for T-ALL cell proliferation in vitro and loss of IGF2BP2 prolonged animal survival in a human T-ALL xenograft model. Mechanistically, IGF2BP2 directly bound to T-ALL oncogene NOTCH1 via an m6A dependent manner. Furthermore, we identified a small-molecule IGF2BP2 inhibitor JX5 and treatment of T-ALL with JX5 showed similar functions as knockdown of IGF2BP2. These findings not only shed light on the role of IGF2BP2 in T-ALL, but also provide an alternative γ‑Secretase inhibitors (GSI) therapy to treat T-ALL. | en_US |
dc.description.abstract | Inhibition of the m6A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Nature | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Inhibition of the m6A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia | en_US |
dc.title.alternative | Inhibition of the m6A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © The Author(s) 2022 | en_US |
dc.source.pagenumber | 2180-2188 | en_US |
dc.source.volume | 36 | en_US |
dc.source.journal | Leukemia | en_US |
dc.identifier.doi | 10.1038/s41375-022-01651-9 | |
dc.identifier.cristin | 2057035 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |