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dc.contributor.authorShikov, Alexander N.
dc.contributor.authorKosman, Vera M.
dc.contributor.authorFlissyuk, Elena V.
dc.contributor.authorSmekhova, Irina E.
dc.contributor.authorElameen, Abdelhameed
dc.contributor.authorPozharitskaya, Olga N.
dc.date.accessioned2021-02-04T18:37:55Z
dc.date.available2021-02-04T18:37:55Z
dc.date.created2020-05-07T15:35:50Z
dc.date.issued2020-04-16
dc.identifier.citationMolecules. 2020, 25 (8), .en_US
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/11250/2726286
dc.description.abstractThe extraction of Rhodiola rosea rhizomes using natural deep eutectic solvent (NADES) consisting of lactic acid, glucose, fructose, and water was investigated. A two-level Plackett–Burman design with five variables, followed by the steepest ascent method, was undertaken to determine the optimal extraction conditions. Among the five parameters tested, particle size, extraction modulus, and water content were found to have the highest impact on the extrability of phenyletanes and phenylpropanoids. The concentration of active compounds was analyzed by HPLC. The predicted results showed that the extraction yield of the total phenyletanes and phenylpropanoids (25.62 mg/g) could be obtained under the following conditions: extraction time of 154 min, extraction temperature of 22 °C, extraction modulus of 40, molar water content of 5:1:11 (L-lactic acid:fructose:water, mol/mol), and a particle size of rhizomes of 0.5–1 mm. These predicted values were further verified by validation experiments in predicted conditions. The experimental yields of salidroside, tyrosol, rosavin, rosin, cinnamyl alcohol and total markers (sum of phenyletanes and phenylpropanoids in mg/g) were 11.90 ± 0.02, 0.36 ± 0.02, 12.23 ± 0.21, 1.41 ± 0.01, 0.20 ± 0.01, and 26.10 ± 0.27 mg/g, respectively, which corresponded well with the predicted values from the models.en_US
dc.language.isoengen_US
dc.publisherMDPI, Basel, Switzerlanden_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleNatural Deep Eutectic Solvents for the Extraction of Phenyletanes and Phenylpropanoids of Rhodiola rosea L.en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2020 by the authorsen_US
dc.source.pagenumber11en_US
dc.source.volume25en_US
dc.source.journalMoleculesen_US
dc.source.issue8en_US
dc.identifier.doi10.3390/molecules25081826
dc.identifier.cristin1809838
dc.source.articlenumber1826en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal